Kirsten, J., Xiong, Y. Davis, C., and Singleton, C.K. (2008). Subcellular
localization of Ammonium transporters in Dictyostelium discoideum.
BMC Cell Biol. 9, 71 PDF
Singleton, Charles K., Kirsten, Janet H. and Dinsmore, Colin J. (2006).
The function of ammonium transporter A in the initiation of culmination
of development in Dictyostelium discoideum. Euk. Cell 5, 991-996.
PDF
Rai, Meena, Xiong, Y., and Singleton, C.K. (2006). Disruption of the ifkA
and ifkB genes results in altered cell adhesion, morphological defects,
and a propensity to form prestalk O cells during development of Dictyostelium.
Differentiation 74,583-595. PDF
Kirsten, J., Xiong, Y, Dunbar, A., Rai, M., and Singleton, C.K. (2005).
Ammonium transporter C of Dictyostelium discoideum is required
for correct prestalk gene expression and for regulating the choice between
slug migration and culmination. Dev. Biol.287, 146-156. PDF
Peter R. Martin, Charles K. Singleton, and Susanne Hiller-Sturmhfel. (2004).
The Role of Thiamine Deficiency in Alcoholic Brain Disease. Alcohol Research
& Health 27, 134-142. PDF
Fang, R., Xiong, Y. and Singleton, C.K. (2003). IfkA, a presumptive eIF2alpha
kinase of Dictyostelium, is required for proper timing of aggregation
and regulation of mound size. BMC-Dev. Biol. 3, 3 (9Apr). PDF
Follstaedt, S., Kirsten, J., and Singelton, C.K. (2003). Temporal and spatial
patterns of expression of ammonium transporters duing the development of
Dictyostelium. Differentiation 71, 557-566 PDF
Song, T. and Singleton, C.K. (2002). Mitochondria from cultured cells derived
from normal and thiamine-responsive megaloblastic anemia individuals efficiently
import thiamine diphosphate. BMC Biochemistry 3, 8. PDF
Singleton, C.K. and Martin, P. R. (2001). Molecular effects of thiamine
deficiency. Current Molecular Medicine 1, 197-207 PDF
Singleton, C. K., (2001). Transketolase. in Encyclopedia of Molecular
Medicine, Thomas E. Creighton, editor. 3224-3226.
Wang, J. J-L., Hua, Z., Fentress, H. M., and Singleton, C. K. (2000). JNK1
is inactivated during thiamine deficiency-induced apoptosis in human neruoblastoma
cells. J. Nutri. Biochem.11, 208-215. PDF
Ragan, P. W., Singleton, C. K., and Martin, P. R. (1999). Brain injury associated
with chronic alcoholism. CNS Spectrums 4, 66-87.
Pekovich, S. R., Martin, P. R., Poggi, V. and Singleton, C. K. (1998). Sensitivity
to thiamine deficiency in cultered human cells is dependent on cell type
and is enhanced in cells from thiamine-responsive megaloblastic anemia patients.
J. Nutri. Biochem. 9, 215-222. PDF
Pekovich, S. T., Martin, P.R., and Singleton, C. K. (1998). Thiamine deficiency
decreases the steady-state mRNA levels for transketolase and pyruvate dehydrogenase
but not for a-ketoglutarate dehydrogenase in three human cell types. J.
Nutr. 128, 683-687. PDF
Zinda, M. J. and Singleton, C. K. (1998). The hybrid histidine kinase dhkB
regulates the spore germination program of Dictyostelium discoideum..
Dev. Biol. 196, 171-183. PDF
Singleton, C. K., Zinda, M. J., Mykytka, B., and Yang, P. (1998). The histidine
kinase dhkC regulates the choice between migrating slugs and terminal
differentiation in Dictyostelium. Dev. Biol. 203, 345-357. PDF
Wang, J. J.-L., Martin, P. R. and Singleton, C. K. (1997). Transketolase
assembly defect in a Wernicke-Korsakoff Syndrome patient. Alc. Clin. Exp.
Res. 21, 576-580. PDF
Wang, J.-L., Martin, P. R., and Singleton, C. K. (1997). Aspartate 155 of
human transketolase is essential for thiamine pyrophosphate-magnesium binding,
and cofactor binding is required for dimer formation. Biochem. et. Biophys.
Acta 1341, 165-172. PDF
Singleton, C. K. (1997). Identification and characterization of the thiamine
transporter gene of Saccharomyces cereviciae. Gene 199, 111-121.
PDF
Pekovich, S. R., Martin, P. R., and Singleton, C. K. (1996). Thiamine pyrophosphate-requiring
enzymes are altered during pyrithiamine-induced thiamine deficiency in cultured
human lymphoblasts. J. Nutrition 126, 1791-1798. PDF
Singleton, C. K., Wang, J. J.-L., Shan, L., and Martin, P. R. (1996). Conserved
residues are functionally distinct within transketolases from different
species. Biochemistry 35, 15865-15869. PDF
Wetterauer, B., Morandini, P., Hribar, I., Murgia-Morandini, I., Hamker,
U., Singleton, C. K., and MacWilliams, H. K. (1996). Wild type strains of
Dictyostelium discoideum can be transformed using a novel selection
cassette driven by the promoter of the ribosomal V18 gene. Plasmid 36, 169-181.
PDF
Singleton, C.K., Pekovich, S.R., McCool, B.A., and Martin, P.R. (1995).
Hysteretic behavior of human transketolase: implications for thiamine deficiency.
J. Nutrition 125, 189-194. PDF
Martin, P. R., McCool, B. A., and Singleton, C. K. (1995). Molecular Genetics
of transketolase and its role in the pathogenesis of the Wernicke-Korsakoff
syndrome. Metab. Brain Disease 10, 45-55.
Ken, R. and Singleton, C.K. (1994). Redundant regulatory elements account
for the developmental control of a ribosomal protein gene from Dictyostelium
discoideum. Differentiation, 55, 97-103.
Martin, P. R., Pekovich, S. R., McCool, B. A., Whetsell, W. O., and Singleton,
C. K. (1994). Thiamine utilization in the pathogenesis of alcohol-induced
brain damage. Alcohol Alcohol. 2S, 273-279. PDF
Martin, P.R., McCool, B.A., and Singleton, C.K. (1993). Genetic sensitivity
to thiamine deficiency and development of alcoholic organic brain disease.
Alcoholism: Clin. and Exp. Res. 17, 31-37.
McCool, B., Plonk, S., Martin, P.R., and Singleton, C.K. (1993). Cloning
of human transketolase cDNAs and comparison of the nucleotide sequence of
the coding region in Wernike-Korsakoff and non-Wernicke-Korsakoff individuals.
J. Biol. Chem. 268,1397-1404. PDF
McPherson, C.E. and Singleton, C.K. (1993). Nutrient responsive promoter
elements of the V4 gene of Dictyostelium discoideum. J. Mol. Biol.
232, 386-396. PDF
McPherson, C.E. and Singleton, C.K. (1992). Nutrient dependent expression
of a vegetative specific gene of Dictyostelium. Biochem. System.
& Ecol. 20, 317-324. PDF
McPherson, C.E. and Singleton, C.K. (1992). V4, a gene required for the
transition from growth to development in Dictyostelium discoideum.
Dev. Biol. 150, 231-242. PDF
Singleton, C.K., Delude, R.L., Ken, R., Manning, S.S., and McPherson, C.E.
(1991). Structure, expression, and regulation of members of the developmentally
controlled V and H gene classes from Dictyostelium. Dev. Genet. 12,
88-97. PDF
Singleton, C.K. (1989). Nucleotide sequence of V1, a ribosomal protein gene
from Dictyostelium discoideum. Nucleic Acids Res. 17, 1989.
Singleton, C.K., Manning, S.S., and Ken, R. (1989). Primary structure and
regulation of vegetative specific genes of Dictyostelium discoideum.
Nucleic Acids Res. 17, 9679-9692. PDF
Singleton, C.K., Manning, S.S., and Feng, Y. (1988). The effect of protein
synthesis inhibition on gene expression during early development of Dictyostelium
discoideum. Mol. Cell. Biol. 8, 10-16. PDF
Singleton, C.K., McPherson, C.E., and Manning, S.S. (1988). Deactivation
of gene expression at the onset of development in Dictyostelium discoideum.
Dev. Genet. 9, 327-335. PDF
Singleton, C.K., Gregoli, P.A., Manning, S.S., and Northington, S.J. (1988).
Characterization of genes which are transiently expressed during the preaggregative
phase of development of Dictyostelium discoideum. Dev. Biol. 129,
140-146. PDF
Singleton, C.K., Delude, R.L., and McPherson, C.E. (1987). Characterization
of genes which are deactivated upon the onset of development in Dictyostelium
discoideum. Dev. Biol. 119, 433-441. PDF
Singleton, C.K. (1987). pPAV, a promoter analysis vector for Dictyostelium
discoideum. Nucleic Acids Res. 15, 9610. PDF