Dr. Patton is a Professor of Biological Sciences at Vanderbilt University in Nashville, TN.
James.G.Patton
Lab Members (Fall 2008) |
| Graduate Students: Elizabeth Thatcher, Nikki Shariat, Nan Li, Amanda Solis, Abby Olena, Kim Anderson, Chunyao Wei
Vanderbilt Undergraduates: Jon Patton, Ima Paydar, Ryan Cleary, Courtney Bartel, Andrew Marshall,
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We study the mechanisms and regulation of pre-mRNA splicing, the role of splicing in disease, and the function of vertebrate microRNAs.Research DescriptionLinkable PublicationsComplete Publication List
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Coding sequences of higher eukaryotic genes are interrupted by noncoding sequences (introns) which must be removed from nascent RNA transcripts (pre- mRNAs) in order to generate mature messages with reading frames competent for translation. The mechanism responsible for these RNA processing events is referred to as splicing. Splicing occurs in a two-step reaction that takes place in a large complex called the spliceosome. For more information, click here
MicroRNAs:
Eukaryotic genomes encode hundreds of microRNAs that function to regulate gene expression primarily byinhibiting translation. These small RNAs are especially important for early development. Larger precursor RNAs are synthesized in the nucleus before export to the cytoplasm for final processing and association with RNA Induced Silencing Complexes.
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