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Elizabeth Thatcher |
Abby Olena |
Chunyao Wei |
Nan Li |
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Kamya Rajaram |
Stacey Lawrence |
Andrew Marshall |
Jasmine Walker |
Lab Members (Summer and Fall 2009) |
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Graduate Students: Elizabeth Thatcher, Nan Li, Abby Olena, Chunyao Wei, Kamya Rajaram Vanderbilt Undergraduates: Courtney Bartel, Andrew Marshall, Summer Students/Rotations: Stacey Lawrence, Jasmine Walker
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We study the mechanisms and regulation of pre-mRNA splicing, the role of splicing in disease, and the function of vertebrate microRNAs.Research DescriptionLinkable PublicationsComplete Publication List
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Coding sequences of higher eukaryotic genes are interrupted by noncoding sequences (introns) which must be removed from nascent RNA transcripts (pre- mRNAs) in order to generate mature messages with reading frames competent for translation. The mechanism responsible for these RNA processing events is referred to as splicing. Splicing occurs in a two-step reaction that takes place in a large complex called the spliceosome. For more information, click here
MicroRNAs:
Eukaryotic genomes encode hundreds of microRNAs that function to regulate gene expression primarily byinhibiting translation. These small RNAs are especially important for early development. Larger precursor RNAs are synthesized in the nucleus before export to the cytoplasm for final processing and association with RNA Induced Silencing Complexes.
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