| Class | Date | Topics | reading |
|---|---|---|---|
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| |||
| 1 | Aug. 25 | Introduction | Ch. 1 |
| 2 | Aug. 27 | Atoms; water; molecular interactions | Sec. 2.1 - 2.4 |
| 3 | Aug. 30 | Biological macromolecules first help session August 31; help sessions on most Tuesdays after this | Sec. 2.4 - 2.5 |
| 4 | Sep. 1 | Proteins: amino acids | Sec. 2.5 pp 51 - 55 |
| 5 | Sep. 3 | Proteins: three-dimensional structure | Sec. 2.5 pp 55 - 75 |
| 6 | Sep. 6 | Enzymes | Sec. 3.2 |
| 7 | Sep. 8 | Membrane lipids | pp 48-51, Sec. 4.1, 4.3 |
| 8 | Sep. 10 | Membrane structure and function | Sec. 4.2, 4.4, 4.5, 4.6 |
| 9 | Sep. 13 | Membrane transport | Sec. 4.7 |
| 10 | Sep. 15 | Organelles | Sec. 1.3, 5.6, 8.1, 8.3, 8.4, 8.6, 8.7 |
| 11 | Sep. 17 | Organelles: protein and lipid transport extra help session at 4:10 on Friday, Sep. 17 | Sec. 8.1, 8.3, 8.5, 8.8 |
| 12 | Sep. 20 | EXAM I (lectures 1 - 10) no help session September 21 | |
| 13 | Sep. 22 | Organelles: mitochondria and chloroplasts | Sec. 5.1, 6.1, 8.9 |
| 14 | Sep. 24 | Introduction to metabolism | Sec. 3.3. A few definitions in 3.1, 3.2, 6.0 |
| 15 | Sep. 27 | Glycolysis and glucose metabolism | Sec. 3.3 |
| 16 | Sep. 29 | The citric acid cycle | Sec. 5.2 |
| 17 | Oct. 1 | Oxidative phosphorylation | Sec. 5.2, 5.3, 5.5 |
| 18 | Oct. 4 | Photosynthesis | Sec. 6.3, 6.4, 6.5, 6.6 |
| 19 | Oct. 6 | The cytoskeleton | Sec. 9.1, 9.3, 9.4, 9.5, 9.7 |
| 20 | Oct. 8 | Cells in tissues extra help session at 4.10 on Friday, Oct. 8 | Sec. 7.1, 7.2, 7.3, 7.4, 7.5 (mainly topics and pictures; text has too much detail for most topics) |
| 21 | Oct. 11 | EXAM II (lectures 11 - 20) no help session October 12 | |
| 22 | Oct. 13 | Genomes and DNA structure | pp 75 - 77, 396 - 410 [410-427: suggested but not required] |
| 23 | Oct. 15 | RNA structure; chromatin structure | pp 484 - 487, 498 - 510 |
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| |||
| 24 | Oct. 20 | Cell cycle and mitosis | pp 579 - 607 |
| 25 | Oct. 22 | DNA Replication | pp 550 - 569 |
| 26 | Oct. 25 | DNA Replication (continued) | |
| 27 | Oct. 27 | DNA Replication (continued) | |
| 28 | Oct. 29 | Mutagenesis and DNA repair | pp 570 - 576 |
| 29 | Nov. 1 | EXAM III (lectures 22 - 28) | |
| 30 | Nov. 3 | Genome organization: molecular structure of the gene | |
| 31 | Nov. 5 | Molecular details of transcription | pp 436 - 470 |
| 32 | Nov. 8 | Molecular details of transcription (continued) | |
| 33 | Nov. 10 | Molecular details of transcription (continued) | |
| 34 | Nov. 12 | Molecular details of translation | pp 470 - 489 |
| 35 | Nov. 15 | Molecular details of translation (continued) | |
| 36 | Nov. 17 | Molecular details of translation (continued) | |
| 37 | Nov. 19 | Molecular details of translation (continued) | |
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| 38 | Nov. 29 | Regulation of gene expression | pp 517 - 538 |
| 39 | Dec. 1 | EXAM III (lectures 30 - 37) | |
| 40 | Dec. 3 | Regulation of gene expression (continued) | pp 517 - 538 [538-547: suggested but not required] |
| 41 | Dec. 6 | Regulation of gene expression (continued) | |
| 42 | Dec. 8 | Regulation of gene expression (continued) |
FINAL EXAMINATION: Monday, December 13, 9:00 am
There will be no
alternate final examination
Text references refer to Cell and
Molecular Biology fourth edition, by Gerald Karp, the textbook in this
course. The lectures are not based directly on the text, and will include some
extra topics and exclude others.
The subjects and dates given here may
not correspond precisely, but hour examinations will be given on the days
scheduled, and will cover the material in the lectures as indicated, regardless
of the actual content of the lectures, unless an exception is announced in
class. Because of the cumulative nature of the material in this course,
questions in examinations may require a knowledge of earlier material. The final
examination will cover all of the material for the semester, but will include a
component based specifically on material covered after the last hour exam.